Histotypic angiogenesis in vitro: Light microscopic, ultrastructural, and radioautographic studies

@article{Nicosia1982HistotypicAI,
  title={Histotypic angiogenesis in vitro: Light microscopic, ultrastructural, and radioautographic studies},
  author={Roberto Francesco Nicosia and Ruy Tchao and Joseph Leighton},
  journal={In Vitro},
  year={1982},
  volume={18},
  pages={538-549}
}
A model for the study of angiogenesis in vitro is described. Rat aortas, cultured in a tridimensional matrix of clotted chick plasma, gave rise to luxuriant outgrowth of vascular channels. We studied this process with light microscopic, radioautographic, and ultrastructural techniques. On the 2nd d of culture, endothelial cells sprouted from the intima of the aorta and its collateral branches into the surrounding clot, forming solid cellular cords. A complex vascular network was established… CONTINUE READING

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