Histotoxic properties of carbon monoxide in the living organ I. Fluorometry of oxidation-reduction state of the rabbit kidney in situ.

@article{Takano1977HistotoxicPO,
  title={Histotoxic properties of carbon monoxide in the living organ I. Fluorometry of oxidation-reduction state of the rabbit kidney in situ.},
  author={Tatsuya Takano and Hirotaka Maeda and Masatake Asano and Satoko Kobayashi and Tsuneyuki Suzuki},
  journal={The Bulletin of Tokyo Medical and Dental University},
  year={1977},
  volume={24 3},
  pages={
          219-22
        }
}
Effect of carbon monoxide on the redox state and blood flow in the renal cortex of the rabbit was examined by the fluorometric method. By a short-period (1-3 min) inhalation of CO in concentrations over 1%, the following were revealed: (1) Reduced pyridine nucleotide was increased, (2) oscillatory change of the reduced pyridine nucleotide, which is characteristic for the histotoxic reaction, developed, and (3) extent of the fluorescence changes tended to be in proportion to the concentration of… CONTINUE READING