History of the worldwide emergence of Kawasaki disease

@article{Burns2018HistoryOT,
  title={History of the worldwide emergence of Kawasaki disease},
  author={Jane C. Burns},
  journal={International Journal of Rheumatic Diseases},
  year={2018},
  volume={21}
}
  • J. Burns
  • Published 19 November 2017
  • Medicine
  • International Journal of Rheumatic Diseases
Dr. Kawasaki saw his first case of the disease that would come to bear his name in 1961. His meticulous description of the clinical syndrome persists as the case definition to the present day. This review chronicles the emergence and recognition of Kawasaki disease in Asia and Western countries and articulates the old disease/new disease controversy. 

Topics from this paper

Kawasaki disease – the journey over 50 years: 1967–2017
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A large number of genetic studies suggest an association between viral super antigens as the origin of Kawasaki disease, where streptococcal pyrogenic exotoxin and toxic shock syndrome toxin 1 play a favorite role.
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This is a rare case of incomplete KD in a neonate, in which timely IVIG administration led to resolution of the acute illness and may have prevented coronary artery aneurysms (CAA).
Kawasaki disease in Colombia: A systematic review and contrast with multisystem inflammatory syndrome in children associated with COVID-19
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The findings of Kawasaki disease in Colombia are consistent with the available descriptions of KD in the scientific literature, and awareness about MIS-C in paediatric patients with COVID-19 and its relationship with KD is raised.
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Cough, diarrhea, vomiting, and sterile pyuria were very common in infant KD patients less than 1 year old, and should be noted in patients with suspected KD for earlier diagnosis and timely treatments.
Indian Academy of Pediatrics Position Paper on Kawasaki Disease
TLDR
Timely diagnosis and initiation of intravenous immunoglobulin (IVIG) therapy is known to produce five-fold reduction in the incidence of CAA and first line of therapy is IVIG, and should be started expeditiously once the diagnosis is made.
Unexpected late-onset aortic valvulitis and moderate regurgitation during longitudinal evaluation of atypical infantile Kawasaki disease: The heart beyond coronaries!
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A child presenting initially with atypical KD and coronary artery aneurysms is described, demonstrating unusual cardiac manifestations of KD and reoriented the protocol for long-term surveillance in infantile KD.
Treatment of Kawasaki Disease: A Network Meta-Analysis of Four Dosage Regimens of Aspirin Combined With Recommended Intravenous Immunoglobulin
TLDR
It is found that treatment without any aspirin is not inferior to other doses of aspirin and can also slightly reduce the risk of CAL.
Phenotype, Susceptibility, Autoimmunity, and Immunotherapy Between Kawasaki Disease and Coronavirus Disease-19 Associated Multisystem Inflammatory Syndrome in Children
TLDR
Based on physiological and pathological immunity of the diseases under genetic susceptibility and host milieu conditions, a series of sequential regimens are provided to develop a so-called “Know thyself, enemy (pathogen), and ever-victorious” strategy for the prevention and immunotherapy of KD and/or MIS-C.
Evaluation of Kawasaki’s disease-associated coronary artery aneurysms with 3D CT cinematic rendering
TLDR
This series of three patients presents the typical coronary artery imaging findings that can appear in these patients, with an emphasis on the use of the novel 3D technique of cinematic rendering (CR).
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