History of the events leading to the formulation of the apoptosis concept.

@article{Kerr2002HistoryOT,
  title={History of the events leading to the formulation of the apoptosis concept.},
  author={John F. R. Kerr},
  journal={Toxicology},
  year={2002},
  volume={181-182},
  pages={
          471-4
        }
}
  • J. Kerr
  • Published 27 December 2002
  • Medicine
  • Toxicology
View on PubMed
celldeath-apoptosis.org
283 Citations
Highly Influential Citations
7
Background Citations
113
Methods Citations
7

283 Citations

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The most recent developments in the biochemical characterization of the many intracellular pathways involved in this complex process are discussed and the use of MRI, MR spectroscopy, and ultrasound as possible alternative imaging modalities for the imaging of apoptosis is addressed.
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The work on mitochondrial cristae remodelling has elucidated a novel checkpoint for apoptosis, which may determine sensitivity to apoptosis in vivo, during adult animal life.
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Apoptosis effector mechanisms: A requiem performed in different keys
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The molecular regulation of caspases and various caspase-independent effectors of apoptosis are discussed, the potential context and/or limitations of these mechanisms are described, and why the understanding of these processes may have relevance in cancer where treatment is believed to engage apoptosis to destroy tumor cells.
Apoptosis in selected liver diseases.
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The role of apoptosis in select important liver diseases is focused on and rational-based strategies are being developed to either promote or suppress apoptotic cell death as a novel therapeutic option in the treatment of these liver diseases.
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References

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Apoptosis: A Basic Biological Phenomenon with Wide-ranging Implications in Tissue Kinetics
TLDR
Apoptosis seems to be involved in cell turnover in many healthy adult tissues and is responsible for focal elimination of cells during normal embryonic development, and participates in at least some types of therapeutically induced tumour regression.
Apoptosis, oncosis, and necrosis. An overview of cell death.
TLDR
Some of the typical features of apoptosis are discussed, such as budding (as opposed to blebbing and zeiosis) and the inflammatory response, and stands in contrast to apoptosis, which leads to necrosis with karyorhexis and cell shrinkage.
Publications in Cell Death: the golden age
Apoptosis or Programmed Cell Death has been among the fastest growing fields in the last decade. Indeed, the number of publications has increased from fewer than 100 in 1990 to over 13 000 in 2000,…
The relationship of acute mesodermal cell death to the teratogenic effects of 7-OHM-12-MBA in the foetal rat.
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An electron‐microscope study of liver cell necrosis due to heliotrine
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