History of the development of azole derivatives.

  • Johan Maertens
  • Published 2004 in
    Clinical microbiology and infection : the…
Until the 1940s, relatively few agents were available for the treatment of systemic fungal infections. The development of the polyene antifungals represented a major advance in medical mycology. Although amphotericin B quickly became the mainstay of therapy for serious infections, its use was associated with infusion-related side-effects and dose-limiting… CONTINUE READING