History of the Development and Evolution of Local Anesthesia Since the Coca Leaf

@article{Calatayud2003HistoryOT,
  title={History of the Development and Evolution of Local Anesthesia Since the Coca Leaf},
  author={Jes{\'u}s Oteo Calatayud and {\'A}ngel Gonz{\'a}lez},
  journal={Anesthesiology},
  year={2003},
  volume={98},
  pages={1503-1508}
}
THE development of anesthesia in general and local anesthetics, in particular, required a cultural change. The concept of pain (especially obstetric pain) was linked to the concept of original sin, and the ability to endure pain was regarded as a sign of character and, in men, was even associated with virility. The change that took place in Western Europe between 1750 and 1850, encompassing the industrialization, progressive humanization, and democratization of society, created an atmosphere… Expand
Local Anesthetics in Dentistry
TLDR
The aim of this chapter will be to introduce the basic pharmacology of local anesthetic agents and to familiarize the reader with the variety of drugs currently available on the market, their unique properties, and potential risks and complications associated with their use. Expand
Local anaesthesia and the dermatologist
TLDR
The potential for toxicity still exists; an inadvertent intravascular injection in a highly vascular area such as the head and neck may produce toxicity; a small, light patient or one with an irritable myocardium may have a lower threshold for developing LA toxicity. Expand
The Anesthesiologist's Armamentarium: From Recreation to Medication and Back.
TLDR
This is the first comprehensive review focusing on the breadth of drugs used by anesthesiologists and describes the historical and recreational use of specific drug classes. Expand
Pain-less injection: principles and pearls
TLDR
It is the authors’ experience that painless injection is achievable by keeping syringes/needles out of sight, proceeding with injection without pre-procedure warning, and engaging patients in a conversation or simple tasks. Expand
Cocaine and the Eye: A Historical Overview
TLDR
Cocaine was brought to Europe after the discovery of America and became the substance most frequently applied for different types of anaesthesia, which triggered off interest in other, less toxic, anaesthetics. Expand
Management of Local Anesthetic Toxicity
TLDR
The overall incidence of local anesthetic systemic toxicity has decreased dramatically over the past 25 years, and the decline is more significant with epidural anesthesia. Expand
Travel medicine, coca and cocaine: demystifying and rehabilitating Erythroxylum – a comprehensive review
  • Irmgard L. Bauer
  • History, Medicine
  • Tropical Diseases, Travel Medicine and Vaccines
  • 2019
TLDR
This article contrasts coca with cocaine in an attempt to explain the differences but also the reasons for this widespread misconception. Expand
The history and progress of local anesthesia: multiple approaches to elongate the action
TLDR
The historical sequence of studies that have been performed in an effort to elongate the action of local anesthetics is presented, referring to epoch-making medical and scientific studies. Expand
DENTAL ANAESTHESIA: AN OVERVIEW
TLDR
The drugs, techniques, complications along with their management, and new development in dental anaesthesia are discussed in detail. Expand
Contradicting a unitary theory of general anesthetic action: a history of three compounds from 1901 to 2001.
TLDR
The legacy of Meyer and Overton has dominated investigations of general anesthetics, but support for their hypothesis was hardly monolithic and three compounds whose actions are inconsistent with the Meyer-Overton hypothesis are focused on. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 84 REFERENCES
Leaves and Needles: The Introduction of Surgical Local Anesthesia
TLDR
The centenary of Koller's contribution offers an opportunity to sketch its dramatic, not to say melodramatic, con­ text, accented with notes from the lullaby of the coca leaves and the early stabs with spinal needles, as well as to reflect on the local anesthesia revolution begun by Carl Koller with cocaine. Expand
Anesthesia and the Development of Surgery (1846–1896)
  • N. M. Greene
  • Medicine
  • Middle East journal of anaesthesiology
  • 1979
The hypothesis that the introduction of anesthesia in 1846 accelerated the development of surgery was tested by compiling statistics on the types of operations performed in this country and abroad inExpand
Effectivity of a new local analgesic Hoe 40 045.
TLDR
It was concluded that Hoe 40 045 2%– adrenaline (5 μg/ml) with a frequency of analgesia close to 100, a duration of analgesIA of 43 min and a latency period of 3 min could be a valuable local analgesic in dental practice. Expand
Dr Horace Wells: the discoverer of general anesthesia.
  • L. F. Menczer, P. Jacobsohn
  • Medicine
  • Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons
  • 1992
TLDR
The authors place in perspective the role each of these men has played and conclude that to Wells belongs the singular honor and title of discoverer of anesthesia. Expand
Applied pharmacology of local anesthetics
Abstract The intelligent and safe use of local anesthetics requires a thorough knowledge of their pharmacological actions, the potentiation of these actions, their toxicity, and the prevention andExpand
The biochemical pharmacology of abused drugs
TLDR
The appeal of LSD is to the introverted who perhaps seek self‐knowledge, and it has been used experimentally as an adiunct to psychotherapy of a range of mental disorders. Expand
Local anesthetic activity and acute toxicity of ( )-2-(N-ethylpropylamino)-2',6'-butyroxylidide, a new long-acting agent.
TLDR
Testing in rat sciatic nerve blocks and guinea pig intradermal wheals showed that the compound has rapid onset, excellent frequency, and long durations of block, and the overall pharmacological and toxicological profile more closely resembles those of bupivacaine and tetracaine than that of lidocaine. Expand
Oral cocaine: plasma concentrations and central effects.
TLDR
Cocaine (2.0 milligrams per kilogram) given by the oral route is at least as effective as the same dose given intranasally, and the subjective "highs" in man are greater after oral than after intranASal administration. Expand
Monografia sobre la coca. La Paz, Bolivia
  • Edita Sociedad Geográfica de la Paz,
  • 1992
Monografia sobre la coca. La Paz, Bolivia
  • Edita Sociedad Geográfica de la Paz,
  • 1992
...
1
2
3
4
5
...