History of the Design of Captopril and Related Inhibitors of Angiotensin Converting Enzyme

@article{Cushman1991HistoryOT,
  title={History of the Design of Captopril and Related Inhibitors of Angiotensin Converting Enzyme},
  author={David W. Cushman and Miguel A. Ondetti},
  journal={Hypertension},
  year={1991},
  volume={17},
  pages={589–592}
}
In describing the development of captopril and related antihypertensive drugs, we hope to resurrect a more specific meaning for the term "drug design," namely, the logical process whereby molecules are constructed for precise fit with a macromolecular receptor. Thus defined, drug design requires direct or indirect knowledge of the nature of the receptor, which in this case is the active center of a peptidase known historically as angiotensin converting enzyme (ACE). We believe that the… 
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Developed models were reviewed according to the applied dataset, descriptors, feature selection methods, model development and validation methods, and the selected descriptors for different datasets and models were compared and discussedaccording to the experimental findings.
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