History of the Concept of Disconnectivity in Schizophrenia.

@article{Coyle2016HistoryOT,
  title={History of the Concept of Disconnectivity in Schizophrenia.},
  author={Joseph T Coyle and Darrick T Balu and Matthew D. Puhl and Glenn T. Konopaske},
  journal={Harvard review of psychiatry},
  year={2016},
  volume={24 2},
  pages={80-6}
}
Nearly 60 years ago Seymour Kety proposed that research on genetics and brain pathology, but not on neurochemistry, would ultimately lead to an understanding of the pathophysiology of schizophrenia. This article will demonstrate the prescience of Kety's proposal; advances in our knowledge of brain structure and genetics have shaped our current understanding of the pathophysiology of schizophrenia. Brain-imaging techniques have shown that schizophrenia is associated with cortical atrophy and… CONTINUE READING
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