History of oncolytic viruses: genesis to genetic engineering.

  title={History of oncolytic viruses: genesis to genetic engineering.},
  author={Elizabeth J. Kelly and Stephen Russell},
  journal={Molecular therapy : the journal of the American Society of Gene Therapy},
  volume={15 4},
Since the turn of the nineteenth century, when their existence was first recognized, viruses have attracted considerable interest as possible agents of tumor destruction. Early case reports emphasized regression of cancers during naturally acquired virus infections, providing the basis for clinical trials where body fluids containing human or animal viruses were used to transmit infections to cancer patients. Most often the viruses were arrested by the host immune system and failed to impact… CONTINUE READING
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