History of genetic disease: Down syndrome and genetics — a case of linked histories

  title={History of genetic disease: Down syndrome and genetics — a case of linked histories},
  author={David Patterson and Alberto C S Costa},
  journal={Nature Reviews Genetics},
Down syndrome, the most common genetic cause of intellectual disabilities, was first described in 1866, during an era of great change in our understanding of genetics and evolution. Because of its importance, the history of research on Down syndrome parallels the history of human genetics. In many instances, research on Down syndrome has inspired progress in human genetics. In this article, we describe the interplay between advances in the understanding of genetics and the understanding of Down… CONTINUE READING

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