For centuries, diapering has been a global practice. Most cultures around the world have historically implemented mechanisms to cover the genital area, both for privacy and to contain waste. The latest and most important innovation was the advent of the disposable diaper in the mid-twentieth century. Modern disposable diapers have considerably decreased the incidence of irritant diaper dermatitis through their design and construction. Disposable diaper use continues to grow globally. This article reviews the history of diaper practices worldwide.