History of biological metal utilization inferred through phylogenomic analysis of protein structures.

  title={History of biological metal utilization inferred through phylogenomic analysis of protein structures.},
  author={Christopher L. Dupont and Andrew Butcher and Ruben E. Valas and Philip E. Bourne and Gustavo Caetano-Anoll{\'e}s},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={107 23},
The fundamental chemistry of trace elements dictates the molecular speciation and reactivity both within cells and the environment at large. Using protein structure and comparative genomics, we elucidate several major influences this chemistry has had upon biology. All of life exhibits the same proteome size-dependent scaling for the number of metal-binding proteins within a proteome. This fundamental evolutionary constant shows that the selection of one element occurs at the exclusion of… CONTINUE READING
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