History of anaesthesia: The ketamine story - past, present and future.

@article{Mion2017HistoryOA,
  title={History of anaesthesia: The ketamine story - past, present and future.},
  author={Georges Mion},
  journal={European Journal of Anaesthesiology},
  year={2017}
}
  • G. Mion
  • Published 1 September 2017
  • Medicine, Biology
  • European Journal of Anaesthesiology
Maddox, a chemist, discovered a process which led to the synthesis of phencyclidine or PCP [N-(1-phenylcyclohexyl)-piperidine] on 26 March 1956. ParkeDavis pharmacologist, Dr Chen, received the compound CI-395 (Fig. 1) from Maddox on 11 September 1958. Chen and, in the same period, Dr Domino, began to study the experimental effects of the drug on animals. Phencyclidine created potent analgesia in animals: laparotomies were performed in monkeys without pain, but the animals were in a cataleptic… 

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