History of Methysergide in Migraine

@article{Koehler2008HistoryOM,
  title={History of Methysergide in Migraine},
  author={Peter J. Koehler and Peer Tfelt-Hansen},
  journal={Cephalalgia},
  year={2008},
  volume={28},
  pages={1126 - 1135}
}
Harold Wolff's theory of vasodilation in migraine is well-known. Less known is his search for a perivascular factor that would damage local tissues and increase pain sensitivity during migraine attacks. Serotonin was found to be among the candidate agents to be included. In the same period, serotonin was isolated (1948) and, because of its actions, an anti-serotonin drug was needed. Methysergide was synthesized from lysergic acid (LSD) by adding a methyl group and a butanolamid group. This… 

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