• DOI:10.5772/66905
• Corpus ID: 56568576

History of Cell Culture

@inproceedings{JedrzejczakSilicka2017HistoryOC,
  title={History of Cell Culture},
  author={Magdalena Jedrzejczak-Silicka},
  year={2017}
}

• Magdalena Jedrzejczak-Silicka
• Published 10 May 2017
• Biology

From the ancient Romans, through the Middle Ages, to the late of the nineteenth cen‐ tury, the Aristotelian doctrine of spontaneous generation was one of the most basic laws. Even the invention of the microscope and investigations of Leeuwenhoek and Hook did not disprove the Aritostelian doctrine. Finally, in the eighteenth century, the spontane‐ ous generation doctrine was laid by Louis Pasteur. Moreover, in the first decade of the eighteenth century, nucleus was observed in plant and animal tissues, and Virchow and other scientists presented the view that cells are formed via scission of preexisting cells. In the first decade of the twentieth century, Ross Harrison developed the first techniques of cell culture in vitro, and Burrows and Carrel improved Harrison's cell cultures. In mid‐twentieth century, the basic principles for plant and animal cell cultures in vitro were developed, and human diploid cell lines were established. On the basis of knowl‐ edge about the cell cycle and gene expression regulation, the first therapeutic proteins were produced using mammalian cell cultures. The end of twentieth century and early twenty‐first century brought the progress in 3‐D cell culture technology and created the possibility of the tissue engineering and the regenerative medicine development.