History of Antibiotics. From Salvarsan to Cephalosporins

@article{Zaffiri2012HistoryOA,
  title={History of Antibiotics. From Salvarsan to Cephalosporins},
  author={Lorenzo Zaffiri and Jared Gardner and Luis H. Toledo-Pereyra},
  journal={Journal of Investigative Surgery},
  year={2012},
  volume={25},
  pages={67 - 77}
}
ABSTRACT Infections have represented for a long time the leading cause of death in humans. During the 19th century, pneumonia, tuberculosis, diarrhea and diphtheria were considered the main causes of death in children and adults. Only in the late 19th century did it become possible to correlate the existence of microscopic pathogens with the development of various diseases. Within a few years the introduction of antiseptic procedures had begun to reduce mortality due to postsurgical infections… 
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References

SHOWING 1-10 OF 183 REFERENCES
Fourth generation cephalosporins in the antimicrobial chemotherapy of surgical infections.
TLDR
Severe surgical infections of nosocomial origin, and particularly in settings where Enterobacter spp predominate, represent the major indication for empirical use of a 4th generation cephalosporin in combination with a nitroimidazole.
Resistance to trimethoprim-sulfamethoxazole.
  • P. Huovinen
  • Medicine, Biology
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
  • 2001
TLDR
Use of TMP-SMZ as prophylaxis for Pneumocystis carinii infection has rapidly increased the multidrug resistance of bacterial pathogens found in human immunodeficiency virus-infected patients.
On the antibacterial action of cultures of a penicillium, with special reference to their use in the isolation of B. influenzae. 1929.
  • A. Fleming
  • Medicine
    Bulletin of the World Health Organization
  • 2001
TLDR
It was found that broth in which the mould had been grown at room temperature for one or two weeks had acquired marked inhibitory, bactericidal and bacteriolytic properties to many of the more common pathogenic bacteria.
Prevention of rheumatic fever; treatment of the preceding streptococcic infection.
TLDR
The prevention of acute rheumatic fever by the prompt treatment of streptococcic infections with penicillin has been attempted and results obtained show that this attempt was successful, and results are presented here in a preliminary report.
On the antibacterial action of cultures of a penicillium, with special reference to their use in the isolation of B. influenzæ
TLDR
It is suggested that it may be an efficient antiseptic for application to, or injection into, areas infected with penicillin-sensitive microbes, and its value as an aid to the isolation of B. influenzae has been demonstrated.
Tuberculostatic and Tuberculocidal Properties of Streptomycin
TLDR
In a comparative study of the bactericidal action of a number of antibiotics, the conclusion was reached that those agents which are characterized by a high bacteriostatic action against a certain organism are also strongly bactericidal.
Antimicrobial Susceptibilities of Brucella Isolates from Various Clinical Speciemens
TLDR
The data suggest that tigecycline can be a therapeutic alternative option for the treatment of brucellosis and in vitro antimicrobial susceptibilities of Brucella strains to commonly used anti-Brucella agents and a possible new alternative tIGecy Cline are determined.
Streptomycin and alternative agents for the treatment of tularemia: review of the literature.
TLDR
Gentamicin is an acceptable alternative to streptomycin for the treatment of tularemia and in vitro susceptibility of Francisella tularensis to a wide variety of agents is reviewed.
The newer penicillins
  • H. Dowling
  • Medicine
    Clinical pharmacology and therapeutics
  • 1961
TLDR
It took some time and a number of teams of research workers to find the structural formula of penicillin, but finally the one shown in Fig. 1 was agreed upon.
...
...