History and therapeutic use of MAO-A inhibitors: a historical perspective of mao-a inhibitors as antidepressant drug.

@article{Yez2012HistoryAT,
  title={History and therapeutic use of MAO-A inhibitors: a historical perspective of mao-a inhibitors as antidepressant drug.},
  author={Matilde Y{\'a}{\~n}ez and Juan Fernando Pad{\'i}n and Juan Alberto Arranz-Tagarro and Mercedes Cami{\~n}a and Reyes Laguna},
  journal={Current topics in medicinal chemistry},
  year={2012},
  volume={12 20},
  pages={
          2275-82
        }
}
Since the first generation of MAO inhibitors was developed, more than fifty years ago, this family of drugs has been ups and downs over the last decades. Actually, interest in MAO inhibitors is reviving and the emergence of new advances in the rational design of molecules and new techniques to predict the in vivo behavior has encouraged the research for new drugs with therapeutic potential in this area. The classic MAOIs have been widely used as antidepressants during the two decades after its… CONTINUE READING