History and principles of conductive media for standard DNA electrophoresis.

  title={History and principles of conductive media for standard DNA electrophoresis.},
  author={Jonathan R. Brody and Scott E. Kern},
  journal={Analytical biochemistry},
  volume={333 1},
DNA electrophoresis has been a dominant technique in molecular biology for 30 years. The foundation for this common technique is based on a few simple electrochemical principles. Electrophoretic DNA separation borrowed from existing protein and RNA techniques developed in the 1950s and 1960s. For 30 years, common DNA electrophoretic conductive media remained largely unchanged, with Tris as the primary cation. DNA electrophoresis relies simply upon the negative charge of the phosphate backbone… CONTINUE READING
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