History and current concepts in the pathogenesis of PML.

  title={History and current concepts in the pathogenesis of PML.},
  author={Eugene O. Major},
  journal={Cleveland Clinic journal of medicine},
  volume={78 Suppl 2},
The JC virus (JCV), first described in 1971, is responsible for initiation of progressive multifocal leukoencephalopathy (PML), a disease characterized by demyelinating plaques and a classic triad of symptoms consisting of cognitive impairment, visual deficits, and motor dysfunction. To establish a diagnosis of PML, evidence of the presence of JCV DNA in pathologic tissue is necessary. The host range for productive infection of JCV is controlled by factors in the cell nucleus that bind to the… CONTINUE READING


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