History, technical and regulatory aspects of exhaled nitric oxide.

@article{Silkoff2008HistoryTA,
  title={History, technical and regulatory aspects of exhaled nitric oxide.},
  author={Philip E Silkoff},
  journal={Journal of breath research},
  year={2008},
  volume={2 3},
  pages={037001}
}
The history of nitric oxide (NO) in exhaled breath as a marker of inflammation is summarized, followed by measurement aspects of exhaled NO including NO excretion models of NO in the airway, the estimation of flow-independent NO exchange parameters and issues with the standardization of these methods. Regulatory considerations in the US are also presented. A brief summary of the state of the art for clinical application of exhaled NO is also included.