History, genetics, and strategies for cancer prevention in Lynch syndrome.

@article{Kastrinos2014HistoryGA,
  title={History, genetics, and strategies for cancer prevention in Lynch syndrome.},
  author={Fay Kastrinos and Elena M. Stoffel},
  journal={Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association},
  year={2014},
  volume={12 5},
  pages={715-27; quiz e41-3}
}
Colorectal cancer (CRC) is the most common gastrointestinal malignancy and the third cause of cancer death in men and women in the United States. The majority of CRC cases diagnosed annually are due to sporadic events, but up to 6% are attributed to known monogenic disorders that confer a markedly increased risk for the development of CRC and multiple extracolonic malignancies. Lynch syndrome is the most common inherited CRC syndrome and is associated with mutations in DNA mismatch repair genes… CONTINUE READING
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