Historical review: Molecular and cellular mechanisms of opiate and cocaine addiction.

  title={Historical review: Molecular and cellular mechanisms of opiate and cocaine addiction.},
  author={Eric J Nestler},
  journal={Trends in pharmacological sciences},
  volume={25 4},
The National Institute on Drug Abuse was founded in 1974, and since that time there have been significant advances in understanding the processes by which drugs of abuse cause addiction. The initial protein targets for almost all drugs of abuse are now known. Animal models that replicate key features of addiction are available, and these models have made it possible to characterize the brain regions that are important for addiction and other drug effects, such as physical dependence. A large… CONTINUE READING
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