Historical perspectives and natural history of bipolar disorder

  title={Historical perspectives and natural history of bipolar disorder},
  author={J. Angst and R. Sellaro},
  journal={Biological Psychiatry},
  • J. Angst, R. Sellaro
  • Published 2000
  • Psychology, Medicine
  • Biological Psychiatry
  • A review of two centuries' literature on the natural history of bipolar disorder, including modern naturalistic studies and new data from a lifelong follow-up study of 220 bipolar patients, reaches the following conclusions: the findings of modern follow-up studies are closely compatible with those of studies conducted before the introduction of modern antidepressant and mood-stabilizing treatments. Bipolar disorder has always been highly recurrent and considered to have a poor prognosis… CONTINUE READING

    Figures, Tables, and Topics from this paper.

    Prevalence and burden of bipolar disorders in European countries
    • 281
    • PDF
    Early stages in the development of bipolar disorder.
    • 237
    • Highly Influenced
    • PDF
    Longitudinal course of bipolar I disorder: duration of mood episodes.
    • 103
    • PDF
    Natural course and burden of bipolar disorders.
    • 67
    • PDF
    ECNP consensus meeting. Bipolar depression. Nice, March 2007
    • 138
    • PDF
    Lithium: Bipolar disorder and neurodegenerative diseases Possible cellular mechanisms of the therapeutic effects of lithium
    • 137
    • Highly Influenced


    Publications referenced by this paper.
    Relapse and impairment in bipolar disorder.
    • 716
    • Highly Influential
    Course of illness and maintenance treatments for patients with bipolar disorder.
    • 165
    Transduction of psychosocial stress into the neurobiology of recurrent affective disorder.
    • 1,628
    Recurrence in affective disorder. I. Case register study.
    • 234
    Major affective disorder as a recurrent illness: a critical review.
    • 175
    • 671
    • PDF
    A prospective follow-up of patients with bipolar and primary unipolar affective disorder.
    • 231
    Bipolar II illness: course and outcome over a five-year period.
    • 154