Historical perspective and recent insights into our understanding of the molecular and biochemical basis of the antitumor properties of mda-7/IL-24.

@article{Emdad2009HistoricalPA,
  title={Historical perspective and recent insights into our understanding of the molecular and biochemical basis of the antitumor properties of mda-7/IL-24.},
  author={Luni Emdad and Irina V. Lebedeva and Zhao-zhong Su and Pankaj Gupta and Moira Sauane and Rupesh Dash and Steven Grant and Paul Dent and David T. Curiel and Devanand Sarkar and Paul B Fisher},
  journal={Cancer biology & therapy},
  year={2009},
  volume={8 5},
  pages={391-400}
}
A subtraction hybridization approach combined with a differentiation therapy model of human melanoma identified melanoma differentiation associated gene-7 (mda-7) as a gene upregulated during induction of terminal differentiation. Based on conserved structure, chromosomal location and cytokine-like properties, mda-7, has now been classified as a member of the expanding interleukin (IL)-10 gene family and designated as mda-7/IL-24. Extensive in vitro and in vivo human tumor xenograft studies… CONTINUE READING
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