Historical opinion: Erwin Chargaff and his 'rules' for the base composition of DNA: why did he fail to see the possibility of complementarity?

@article{Manchester2008HistoricalOE,
  title={Historical opinion: Erwin Chargaff and his 'rules' for the base composition of DNA: why did he fail to see the possibility of complementarity?},
  author={Keith L. Manchester},
  journal={Trends in biochemical sciences},
  year={2008},
  volume={33 2},
  pages={
          65-70
        }
}
  • K. Manchester
  • Published 1 February 2008
  • Art
  • Trends in biochemical sciences

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References

SHOWING 1-10 OF 48 REFERENCES
Molecular Structure of Nucleic Acids: A Structure for Deoxyribose Nucleic Acid
TLDR
The determination in 1953 of the structure of deoxyribonucleic acid (DNA), with its two entwined helices and paired organic bases, was a tour de force in X-ray crystallography and opened the way for a deeper understanding of perhaps the most important biological process.
Oswald Theodore Avery and DNA
  • A. Coburn
  • History
    Perspectives in biology and medicine
  • 1969
To one who had no scientific association with Avery's work it seems appropriate to place the following information on the record. I am motivated to make this report because repeatedly I note that
The third man of the double helix
TLDR
In this autobiographical book, Maurice Wilkins presents the chronological story of the discovery of DNA structure in 1953, and describes the research team under Professor Randall at King's College, London, also called 'Randall's Circus'.
The composition of the deoxyribonucleic acid of salmon sperm.
Structure of the Nucleic Acids
WE have formulated a structure for the nucleic acids which is compatible with the main features of the X-ray diagram and with the general principles of molecular structure, and which accounts
Molecular Shape and Size of Thymonucleic Acid
A STUDY has been made of the viscosity and the double refraction of flow of thymonucleic acid in water solution. The sodium salt of the acid was prepared according to the method of Hammarsten1, and
Molecular basis of biological specificity
Linus Pauling reviews his work on the molecular basis of biological specificity and remembers his erroneous conception of a three-chain helix structure for DNA in 1952.
The Chemistry of the Nucleic Acids and Nucleoproteins
TLDR
It is suggested that nucleoproteins prepared thus are of variable composition, the precipitated nucleic acid carrying with it varying quantities of loosely bound protein, and these methods are now considered unsatisfactory in view of the possible rupture of the nucleic Acid-protein bond during the acid precipitation.
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4
5
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