Historical lessons in translational medicine: cyclooxygenase inhibition and P2Y12 antagonism.

  title={Historical lessons in translational medicine: cyclooxygenase inhibition and P2Y12 antagonism.},
  author={Desmond J. Fitzgerald and Garret A. FitzGerald},
  journal={Circulation research},
  volume={112 1},
The development of drugs that inhibit platelets has been driven by a combination of clinical insights, fundamental science, and sheer luck. The process has evolved as the days of stumbling on therapeutic gems, such as aspirin, have long passed and have been replaced by an arduous process in which a drug is designed to target a specific protein implicated in a well-characterized pathophysiological process, or so we would like to believe. The development of antiplatelet therapy illustrates the… CONTINUE READING
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