Historical blunders: how toxicology got the dose-response relationship half right.

@article{Calabrese2005HistoricalBH,
  title={Historical blunders: how toxicology got the dose-response relationship half right.},
  author={Edward J. Calabrese},
  journal={Cellular and molecular biology},
  year={2005},
  volume={51 7},
  pages={643-54}
}
Substantial evidence indicates that reliable examples of hormetic dose responses in the toxicological literature are common and generalizable across biological model, endpoint measured and chemical class. Further evaluation revealed that the hormetic dose response model is more common than the threshold dose response model in objective, head-to-head comparisons. Nonetheless, the field of toxicology made a profound error by rejecting the use of the hormetic dose response model in its teaching… CONTINUE READING

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