Historical analysis of PAI-1 from its discovery to its potential role in cell motility and disease.

@article{Dellas2005HistoricalAO,
  title={Historical analysis of PAI-1 from its discovery to its potential role in cell motility and disease.},
  author={Claudia Dellas and David J. Loskutoff},
  journal={Thrombosis and haemostasis},
  year={2005},
  volume={93 4},
  pages={
          631-40
        }
}
Although plasminogen activator inhibitor 1 (PAI-1) is one of the primary regulators of the fibrinolytic system, it also has dramatic effects on cell adhesion, detachment and migration. PAI-1 also differs from other serine protease inhibitors (serpins) in that it is a trace protein in plasma, it has a short half-life in vivo, its synthesis is highly regulated, and it binds to the adhesive glycoprotein vitronectin (VN) with high affinity and specificity. These unique and diverse properties of PAI… 
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Small Molecule Targeting of PAI-1 Function: A New Therapeutic Approach for Treatment of Vascular Stenosis
TLDR
These findings implicate PAI-1 as a significant factor in the development of restenosis and provided the impetus for development of low-molecular weight PAi-1 antagonists.
Heterogeneous glycosylation patterns of human PAI-1 may reveal its cellular origin.
Three decades of research on plasminogen activator inhibitor-1: a multifaceted serpin.
TLDR
The review provides an overview on the current knowledge on PAI-1, a unique member of the serpin superfamily, exhibiting particular unique conformational and functional properties in the plasminogen-plasmin system.
Resolving distinct molecular origins for copper effects on PAI-1
TLDR
A gel-based copper sensitivity assay is developed that can be used to assess the copper concentrations that accelerate the conversion of active PAI-1 to a latent form, and identified a copper-binding site involving histidines at positions 2 and 3 that confers a remarkable stabilization of PAi-1 beyond what is observed with vitronectin alone.
Biochemical properties of plasminogen activator inhibitor-1.
TLDR
Studies of PAI-1 have contributed significantly to the elucidation of the protease inhibitory mechanism of serpins, which is based on a metastable native state becoming stabilised by insertion of the RCL into the central beta-sheet A and formation of covalent complexes with target proteases.
Emerging role of serpinE2/protease nexin-1 in hemostasis and vascular biology.
TLDR
Recent data underlining the emerging role of PN-1 as a key factor in the responses of vessels to injury are reviewed, providing insights that may allow the development of drugs and treatment strategies to prevent or limit thrombotic disorders.
Plasminogen Activator Inhibitor 1 in Platelets - Studies of Synthesis, Activity, and Glycosylation Patterns
TLDR
The role of platelets in inhibition of fibrinolysis, and in particular the physiological regulation of platelet-derived PAI-1; its synthesis, activity, and potential contribution to plasma levels is investigated to clarify the previous irreconcilable findings.
Plasminogen activator inhibitor-1 in cancer research.
Inhibition of Plasminogen Activator Inhibitor-1: Its Mechanism and Effectiveness on Coagulation and Fibrosis
TLDR
Beneficial in vitro and in vivo effects of novel PAI-1 inhibitors are demonstrated and the methodology proves to be a useful tool to obtain effective inhibitors of serpin activity.
Plasminogen activator inhibitor-1 is locked in active conformation and polymerizes upon binding ligands neutralizing its activity.
TLDR
It is found that some inhibitors of PAI-1 arrest this serpin in its active form instead of increasing the speed of conversion, which abolishing a necessary step in the conversion of this protein into the latent form.
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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