Historical analysis of PAI-1 from its discovery to its potential role in cell motility and disease.

@article{Dellas2005HistoricalAO,
  title={Historical analysis of PAI-1 from its discovery to its potential role in cell motility and disease.},
  author={Claudia Dellas and David J. Loskutoff},
  journal={Thrombosis and haemostasis},
  year={2005},
  volume={93 4},
  pages={631-40}
}
Although plasminogen activator inhibitor 1 (PAI-1) is one of the primary regulators of the fibrinolytic system, it also has dramatic effects on cell adhesion, detachment and migration. PAI-1 also differs from other serine protease inhibitors (serpins) in that it is a trace protein in plasma, it has a short half-life in vivo, its synthesis is highly regulated, and it binds to the adhesive glycoprotein vitronectin (VN) with high affinity and specificity. These unique and diverse properties of PAI… CONTINUE READING

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Synthesis and localization of PAI-1 in the vessel wall

  • C Fearns, F Samad, DJ. Loskutoff
  • Advances in Vacular Biology
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Highly Influential
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