Historical Perspectives in Kidney Transplantation: An Updated Review

  title={Historical Perspectives in Kidney Transplantation: An Updated Review},
  author={Badri Man Shrestha and John Haylor and Andrew Thomas Raftery},
  journal={Progress in Transplantation},
  pages={64 - 76}
The present state of success in kidney transplantation, including its benefits to patients with end-stage renal failure, was achieved through relentless research, both in experimental animal models and human volunteers. Kidney transplantation has evolved during the past century thanks to various milestones in surgical techniques, immunology, immunosuppressive drugs, expansion of donor sources, organ preservation, transplant against immunological barriers (ABO blood group-incompatible and… 
Analysis of 4000 kidney transplantations in a single center
Clinical outcomes in ABOi and flow-cytometric crossmatch (FCXM) positive KT showed no significant differences in comparison with ABO-compatible KT if adequate immunosuppressive treatment was performed, and it was suggested that ABO or FCXM positive KTs can be performed safely with successful graft outcomes.
2222 kidney transplantations at the University Hospital Basel: a story of success and new challenges.
Despite increasing donor and recipient age, outcomes improved, illustrating ongoing progress in kidney transplantation and a major new challenge to match the functional capacity of the donor organ with the anticipated lifespan of the recipient.
The pig as an animal model for kidney transplantation
The present study confirmed that the pig constitutes an excellent animal model for kidney transplantation studies and could reduce IRI and thus help to prevent rejection of a transplanted kidney.
Immunosuppression Minimization and Avoidance Protocols: When Less Is Not More.
It is suggested that chronic alloimmune damage rather than chronic CNI nephrotoxicity is the major contributor to late kidney allograft failure.
Renal transplant immunology in the last 20 years: A revolution towards graft and patient survival improvement
This review presents an historical and clinical perspective of those important advances in kidney transplantation immunology in the last 20 years, which contributed to the improvement in patients’ quality of life and the survival of end-stage renal patients.
Underlying Causes and Risk Factors of Chronic Renal Allograft Dysfunction Among Renal Transplant Recipients
Delayed graft function, presence and the number of acute rejections, increased cold ischemia time, panel reactive antibodyPositivity, donor specific antibodies positivity, and thenumber of human leukocyte antigens mismatches were risk factors for chronic allograft dysfunction.
Clinical Features of Kidney Transplant Recipients Admitted to the Intensive Care Unit
Sepsis was the main reason for ICU admission in kidney transplant recipients, followed by cardiovascular disease, and age and disease severity were associated with hospital mortality.


Factors influencing long-term outcomes following renal transplantation: a review.
In this review, each factor influencing the long-term graft function in the donor and recipient pre- and post-transplantation is discussed in the context of current transplant practice and an up to date review of literature is presented.
Advances in immunosuppression for renal transplantation
Several compounds that have been developed to remove allogenic T cells and/or to inhibit T-cell activation are reported on and compounds that interfere with antibody-mediated rejection are discussed.
Therapeutic Apheresis Therapy for ABO‐incompatible Renal Transplantations
  • H. IshidaK. TanabeH. TomaT. Akiba
  • Medicine
    Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy
  • 2003
The historical background, the current therapeutic strategies including apheresis therapy for the ABO‐incompatible transplantations, and the experiences at this institution are described.
Transplantation tolerance through mixed chimerism
This Review addresses recent advances in preclinical and clinical studies inducing transplantation tolerance through mixed chimerism and discusses both the potential and the challenges of this approach.
Technical Aspects of Unilateral Dual Kidney Transplantation from Expanded Criteria Donors: Experience of 100 Patients
  • B. EkserL. Furian P. Rigotti
  • Medicine
    American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
  • 2010
Dual kidney transplantation (UDKT) can be carried out with comparable surgical complication rates as SKT, leaving the contralateral iliac fossa untouched and giving elderly recipients a better chance of receiving a transplant, with optimal results up to 3‐years follow‐up.
Quality of life following live donor renal transplantation: a single centre experience.
LDRTx significantly improved QoL, which was best with preemptive transplantation and tacrolimus-based immunosuppressive regimens.
Strategies to improve long-term outcomes after renal transplantation.
Current antirejection therapy, including calcineurin blockers such as cyclosporine and tacrolimus, the interleukin-2 signal-transduction inhibitor sirolimus and the purine-synthesis inhibitor mycophenolate mofetil are discussed, which inhibits the proliferation of T cells and B cells.