Histoplasmosis of the Central Nervous System

  title={Histoplasmosis of the Central Nervous System},
  author={David Trofa and Joshua Daniel Nosanchuk},
  journal={Journal of neuroinfectious diseases},
Histoplasmosis of the central nervous system (CNS) is not an uncommon complication of Histoplasma capsulatum infection since it occurs in ∼2% to 20% of disseminated cases. CNS histoplasmosis carries a mortality rate that ranges from 11.1% to 100%, and the risk factors for dissemination to the brain have yet to be determined. Diagnosis is often difficult and time consuming, which can result in delayed initiation of treatment. The recommended treatment for CNS histoplasmosis involves a high dose… 

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