Histoplasma capsulatum depends on de novo vitamin biosynthesis for intraphagosomal proliferation.

  title={Histoplasma capsulatum depends on de novo vitamin biosynthesis for intraphagosomal proliferation.},
  author={Andrew L. Garfoot and Olga Zemska and Chad A Rappleye},
  journal={Infection and immunity},
  volume={82 1},
During infection of the mammalian host, Histoplasma capsulatum yeasts survive and reside within macrophages of the immune system. Whereas some intracellular pathogens escape into the host cytosol, Histoplasma yeasts remain within the macrophage phagosome. This intracellular Histoplasma-containing compartment imposes nutritional challenges for yeast growth and replication. We identified and annotated vitamin synthesis pathways encoded in the Histoplasma genome and confirmed by growth in minimal… CONTINUE READING
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