The functional state of the endocrine organs during development of the stress response largely depends on interaction between the systems responsible for realization and limitation of that response . Data on the effect of an altered emotional status on the pituitary-thyroid complex and of its component -the thyroid gland (TG) -are quite contradictory [2-4]. The stress-realizing effect of catecholamines is known to be largely blocked by stimulation of the group of endogenous opioids [9, 14]. Questions of interaction between organs responsible for the development of the general adaptation syndrome are very important in connection with interpretation of the mechanisms of development of neuroendocrine disturbances. The aim of the present investigation was to study the histophysiological parameters of TG during emotional stress and additional involvement of the systems limiting the stress reaction.