• Medicine
  • Published in
    The Journal of heart…
    1987

Histopathology of acute myocardial necrosis: effects of immunosuppression therapy.

@article{Carrier1987HistopathologyOA,
  title={Histopathology of acute myocardial necrosis: effects of immunosuppression therapy.},
  author={Michel Carrier and Samuel H. Paplanus and Anna R. Graham and Jack G. Copeland},
  journal={The Journal of heart transplantation},
  year={1987},
  volume={6 4},
  pages={
          218-21
        }
}
Endomyocardial biopsy is currently the best method to monitor cardiac allograft rejection. The histologic criteria of infiltration by mononuclear cells with pyroninophilic cytoplasm and acute myocyte necrosis indicate immunologic activation and require an increase of immunosuppressive therapy. Of particular concern is the persistence of necrotic fibers on biopsies for some time after ischemic episodes associated with the transplant procedure and after acute rejection episodes. Because the… CONTINUE READING