Histopathology and molecular basis of iridogoniodysgenesis syndrome.

@article{Pearce1999HistopathologyAM,
  title={Histopathology and molecular basis of iridogoniodysgenesis syndrome.},
  author={W. G. Pearce and B. Mielke and S. Kulak and M. Walter},
  journal={Ophthalmic genetics},
  year={1999},
  volume={20 2},
  pages={
          83-8
        }
}
  • W. G. Pearce, B. Mielke, +1 author M. Walter
  • Published 1999
  • Biology, Medicine
  • Ophthalmic genetics
  • Iridogoniodysgenesis is an autosomal dominant disorder in which there are abnormalities in the development of the iris stroma and trabecular meshwork tissues commonly resulting in glaucoma. The unoperated eye from an affected member of a family with iridogoniodysgenesis syndrome (IGDS) was removed shortly after death. Histopathological studies showed an incomplete, normally positioned line of Schwalbe and iris stromal hypoplasia. The molecular basis underlying the disorder is a missense… CONTINUE READING
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    References

    SHOWING 1-10 OF 13 REFERENCES
    Familial hypoplasia of the iris stroma associated with glaucoma.
    • 49
    • PDF
    A second locus for Rieger syndrome maps to chromosome 13q14.
    • 179
    Familial glaucoma. In nine generations of a South Hampshire family.
    • 29
    • PDF
    ERBLICHES JUGENDLICHES GLAUKOM
    • 33
    Autosomal dominant Axenfeld-Rieger anomaly maps to 6p25.
    • 56
    Common BRCA1 variants and transcriptional activation.
    • 40