Histopathological studies on the local reactions induced by complete Freund's adjuvant (CFA), bacterial lipopolysaccharide (LPS), and synthetic lipopeptide (P3C) conjugates.

@article{Wiedemann1991HistopathologicalSO,
  title={Histopathological studies on the local reactions induced by complete Freund's adjuvant (CFA), bacterial lipopolysaccharide (LPS), and synthetic lipopeptide (P3C) conjugates.},
  author={Fritz Wiedemann and Reinhard Link and K Pumpe and U Jacobshagen and Hans Eckart Schaefer and K. H. Wiesm{\"u}ller and Robert P. Hummel and Gbap Jung and Wolfgang Bessler and Traudel B{\"o}ltz},
  journal={The Journal of pathology},
  year={1991},
  volume={164 3},
  pages={
          265-71
        }
}
  • Fritz Wiedemann, Reinhard Link, +7 authors Traudel Böltz
  • Published in The Journal of pathology 1991
  • Medicine
  • The inflammatory reactions following subcutaneous application of adjuvants revealed characteristic pathological patterns. The injection of complete Freund's adjuvant (CFA) resulted in the formation of large lipid deposits encircled by an inflammatory reaction and concentrically arranged collagen bundles. Bacterial lipopolysaccharide (LPS) caused granulomatous aggregations of mononuclear cells with thrombotic vessel occlusions. Inoculation of the lipopeptide adjuvants induced accumulation of… CONTINUE READING

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