Histopathological studies of staphylococcal alpha-toxin: effects on rabbit corneas.

@article{Moreau1997HistopathologicalSO,
  title={Histopathological studies of staphylococcal alpha-toxin: effects on rabbit corneas.},
  author={Judy M Moreau and Gregory D. Sloop and Lee S. Engel and James A. Hill and Richard J O'Callaghan},
  journal={Current eye research},
  year={1997},
  volume={16 12},
  pages={
          1221-8
        }
}
PURPOSE Previous studies from this laboratory have demonstrated, in a rabbit model of keratitis, a relationship between the corneal virulence of Staphylococcus aureus and the alpha-toxin activity of the infecting bacteria. This study is a histopathological characterization of the action of purified alpha-toxin on corneal tissue. METHODS Alpha-toxin was purified by isoelectric focusing and intrastromally injected into rabbit corneas (2 micrograms per cornea). A kinetic analysis of toxin effect… CONTINUE READING
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