Histopathological studies of staphylococcal alpha-toxin: effects on rabbit corneas.


PURPOSE Previous studies from this laboratory have demonstrated, in a rabbit model of keratitis, a relationship between the corneal virulence of Staphylococcus aureus and the alpha-toxin activity of the infecting bacteria. This study is a histopathological characterization of the action of purified alpha-toxin on corneal tissue. METHODS Alpha-toxin was… (More)