Histopathological evaluation of rat urinary bladders from the IRDC two-generation bioassay of sodium saccharin.

@article{Squire1985HistopathologicalEO,
  title={Histopathological evaluation of rat urinary bladders from the IRDC two-generation bioassay of sodium saccharin.},
  author={Robert A. Squire},
  journal={Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association},
  year={1985},
  volume={23 4-5},
  pages={491-7}
}
  • Robert A. Squire
  • Published 1985 in
    Food and chemical toxicology : an international…
Bladder tissues from rats treated with sodium saccharin in a two-generation dose-response study, in which 1.0% in the diet had been identified as the no-effect level for primary bladder cancer, were re-examined without knowledge of the test groups or the previous histopathological findings. Compound-related increases in the incidences of hyperplasia were found at the 6.25 and 7.5% saccharin levels (the highest dietary levels tested). There were also compound-related increased in the incidence… CONTINUE READING