Histopathological differences of myotonic dystrophy type 1 (DM1) and PROMM/DM2.

  title={Histopathological differences of myotonic dystrophy type 1 (DM1) and PROMM/DM2.},
  author={A Vihola and Guillaume Bassez and Giovanni Meola and Shuo Zhang and Hannu Kalervo Haapasalo and Anders E Paetau and Enzo Mancinelli and Andr{\'e}e Rouche and Jean-Yves Hogrel and Pascal Lafor{\^e}t and Thierry Maisonobe and Jean François Pellissier and Ralf Krahe and Bruno Eymard and Bjarne A. Udd},
  volume={60 11},
Muscle biopsy findings in DM2 have been reported to be similar to those in DM1. The authors used myosin heavy chain immunohistochemistry and enzyme histochemistry for fiber type differentiation on muscle biopsies. Their results show that DM2 patients display a subpopulation of type 2 nuclear clump and other very small fibers and, hence, preferential type 2 fiber atrophy in contrast to type 1 fiber atrophy in DM1 patients. 
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