Histopathological characterisation of effects of the mouse Pax6(Leca4) missense mutation on eye development.

@article{Ramaesh2009HistopathologicalCO,
  title={Histopathological characterisation of effects of the mouse Pax6(Leca4) missense mutation on eye development.},
  author={Thaya Ramaesh and Steven E. Williams and Catriona Paul and Kanna Ramaesh and Baljean Dhillon and John D. West},
  journal={Experimental eye research},
  year={2009},
  volume={89 2},
  pages={263-73}
}
Mutations in PAX6/Pax6 lead to a variety of ocular anomalies in humans and mice. The aim of the study was to characterise the ocular abnormalities caused by the missense Pax6(Leca4) mutation and compare them to published observations on Pax6 alleles that are functionally equivalent to Pax6(-) null alleles (such as Pax6(Sey) and Pax6(Sey-Neu)) and human inherited eye diseases. Ocular features of homozygous Pax6(Leca4)(/Leca4) and heterozygous Pax6(Leca4)(/+) embryos at E12.5-E18.5, heterozygous… CONTINUE READING