Histopathological changes in the liver following a paracetamol overdose: correlation with clinical and biochemical parameters.

@article{Portmann1975HistopathologicalCI,
  title={Histopathological changes in the liver following a paracetamol overdose: correlation with clinical and biochemical parameters.},
  author={Bernard Portmann and Ian C. Talbot and Donald Day and Anne Davidson and Iain M. Murray-Lyon and Roger Williams},
  journal={The Journal of pathology},
  year={1975},
  volume={117 3},
  pages={169-81}
}
The histological appearances of the liver damage occurring after a paracetamol overdose are described in liver biopsies from 104 patients, of whom 38 developed fulminant hepatic failure. Confluent centrilobular necrosis of varying extent was followed by rapid disappearance of necrotic cells, leaving areas of reticulin collapse and a usually mild inflammatory reaction. The histological recovery in even the most severe cases was remarkable, and only one of the 17 survivors whose initial biopsy… CONTINUE READING