Histopathological and hemodynamic consequences of complete versus incomplete ischemia in the rat.

@article{Dietrich1987HistopathologicalAH,
  title={Histopathological and hemodynamic consequences of complete versus incomplete ischemia in the rat.},
  author={W. Dalton Dietrich and R. Fern{\'a}ndez del Busto and Shinichi Yoshida and Myron D. Ginsberg},
  journal={Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism},
  year={1987},
  volume={7 3},
  pages={
          300-8
        }
}
The primary objective of this study was to compare the histopathological consequences of complete versus incomplete ischemia under experimental conditions that limit lactate accumulation. Fasted rats underwent 1 h of either complete or incomplete ischemia by a procedure combining bilateral common carotid artery occlusion, halothane-induced systemic hypotension, and CSF pressure elevation. Histopathological outcome was evaluated 4 h later and was graded on a 4-point scale. Incomplete ischemia… CONTINUE READING
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