Histopathological and biochemical changes in guinea pigs after repeated dermal exposure to benzene hexachloride.

@article{Dikshith1978HistopathologicalAB,
  title={Histopathological and biochemical changes in guinea pigs after repeated dermal exposure to benzene hexachloride.},
  author={T. S. S. Dikshith and Kamal K. Datta and Hukum Singh Kushwah and Rajendra Behari Raizada},
  journal={Toxicology},
  year={1978},
  volume={10 1},
  pages={55-66}
}
Dermal application of benzene hexachloride in daily doses of 100, 200 and 500 mg/kg for a total period of 30 days caused significant changes in male guinea pigs. The animals exposed to high doses of benzene hexachloride (1,2,3,4,5,6-hexachlorocyclohexane) (BHC) (BHC) died within 5--12 days. There was no mortality in 100 mg/kg/day but significant pathologic and biochemical changes were observed in the vital organs of the experimental animals. Massive congestion and thickened blood vessels were… CONTINUE READING