Histopathological analyses of silent pituitary somatotroph adenomas using immunohistochemistry, in situ hybridization and confocal laser scanning microscopic observation.

@article{Matsuno2001HistopathologicalAO,
  title={Histopathological analyses of silent pituitary somatotroph adenomas using immunohistochemistry, in situ hybridization and confocal laser scanning microscopic observation.},
  author={Akira Matsuno and Johbu Itoh and Yoshiko Itoh and Robert Yoshiyuki Osamura and Haruko Katayama and Tadashi Nagashima},
  journal={Pathology, research and practice},
  year={2001},
  volume={197 1},
  pages={13-20}
}
To characterize the morphological and functional aspects of silent somatotroph adenomas with paradoxical responses of GH in TRH or GnRH provocation tests, which are considered to be a useful strategy for endocrinological identification of silent somatotroph adenomas, we examined three silent somatotroph adenomas histopathologically. The adenomas were investigated by immunohistochemistry, including the highly sensitive catalyzed signal amplification system, the non-radioisotopic in situ… CONTINUE READING