Evaluation of Acetamiprid Mediated Oxidative Stress and Pathological Changes in Male Rats: Ameliorative Effect of Curcumin
Repeated oral administration of 10 mg/kg/day thiacloprid, a neonicotinoid insecticide, for 28 consecutive days in Gallus domesticus, resulted in significant changes in the gross morphology of liver, lungs and intestine but no alterations in the kidneys, brain, heart and ovaries. Histopathologically significant alterations in the liver were observed, such as mild fatty changes, congestion and degeneration of hepatocytes. Alterations in the histoarchitecture of the kidneys included marked congestion, tubular cell degeneration and sloughing of epithelial cells. The cerebral hemisphere revealed changes comprising of mild neuronal degeneration with surrounding glial cells, satellitosis and vacuolation. Mild congestion and haemorrhage was observed in the lungs and myocardial tissues following oral administration of thiacloprid. No adverse effect on the ovarian histoarchitecture and thus the reproductive performance of Gallus domesticus was seen. The oral sub-acute toxicity study of thiacloprid revealed that this neonicotinoid insecticide is of moderate risk in Gallus domesticus.