Histopathological Changes of Inner Retina, Optic Disc, and Optic Nerve in Rabbit with Advanced Retinitis Pigmentosa

@article{Asakawa2016HistopathologicalCO,
  title={Histopathological Changes of Inner Retina, Optic Disc, and Optic Nerve in Rabbit with Advanced Retinitis Pigmentosa},
  author={K. Asakawa and H. Ishikawa and S. Uga and K. Mashimo and M. Kondo and H. Terasaki},
  journal={Neuro-Ophthalmology},
  year={2016},
  volume={40},
  pages={286 - 291}
}
ABSTRACT We observed the histopathological changes of retinal ganglion cells (RGCs), optic disc, and optic nerve in rabbit with advanced retinitis pigmentosa (RP). Wild-type (WT) and rhodopsin transgenic (Tg) of RP rabbits were used at age 24 months. Light and electron microscopy were used to observe the retina, optic disc, and optic nerve. RGCs were also confirmed by immunofluorescent staining with a TUJ-1 monoclonal antibody. In addition to the rod and cone degeneration, we observed the… Expand
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