Histopathologic spectrum and immunohistochemical diagnosis of amebic meningoencephalitis

  title={Histopathologic spectrum and immunohistochemical diagnosis of amebic meningoencephalitis},
  author={Jeannette Guarner and Jeanine Bartlett and W. J. Shieh and Christopher D Paddock and Govinda S. Visvesvara and Sherif R. Zaki},
  journal={Modern Pathology},
Traditionally, Naegleria fowleri infections are labeled primary amebic meningoencephalitis because of prominent meningeal neutrophilic inflammation. Acanthamoeba spp. and Balamuthia mandrillaris are labeled granulomatous amebic encephalitis because of parenchymal granulomatous inflammation. We compared histopathologic and immunohistochemical features of 18 cases with central nervous system free-living ameba infections. Immunohistochemical assays using polyclonal antibodies that reacted… CONTINUE READING
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