Histopathologic investigations of the unphonated human vocal fold mucosa

@article{Sato2008HistopathologicIO,
  title={Histopathologic investigations of the unphonated human vocal fold mucosa},
  author={Kiminori Sato and Tadashi Nakashima and Satoshi Nonaka and Yasuaki Harabuchi},
  journal={Acta Oto-Laryngologica},
  year={2008},
  volume={128},
  pages={694 - 701}
}
Conclusion. Vocal fold vibration (phonation) after birth is one of the important factors in the growth and development of the human vocal fold mucosa. Objectives. Stellate cells in the maculae flavae located at both ends of the vocal fold mucosa are inferred to be involved in the metabolism of extracellular matrices. Maculae flavae are also considered to be an important structure in the growth and development of the human vocal fold mucosa. Tension caused by phonation (vocal fold vibration) is… 
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TLDR
Vocal fold vibration (phonation) after birth is an important factor in the growth and development of the human vocal fold mucosa.
Histopathologic study of human vocal fold mucosa unphonated over a decade
Abstract Conclusion: Mechanotransduction caused by vocal fold vibration could possibly be an important factor in the maintenance of extracellular matrices and layered structure of the human adult
Mechanical Regulation (Cellular Mechanotransduction) of the Human Vocal Fold Mucosa
TLDR
The latest studies have supported the hypothesis that the tension caused by phonation (vocal fold vibration) after birth stimulates cells including vocal fold stellate cells in the anterior and posterior maculae flavae to accelerate production of extracellular matrices and form the vocal ligament, Reinke’s space and the characteristic layered structure.
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1. Newborns already have immature maculae flavae at the same sites as adults. They are composed of dense masses of cells including vocal fold stellate cells, whereas extracellular matrix
Expression and Distribution of Hyaluronic Acid and CD44 in Unphonated Human Vocal Fold Mucosa
TLDR
This study supports the hypothesis that the tensions caused by vocal fold vibration stimulate the VFSCs in the MFe to accelerate production of extracellular matrices and form the layered structure.
Expression and Distribution of Hyaluronic Acid and CD44 in Unphonated Human Vocal Fold Mucosa
TLDR
The hypothesis that the tensions caused by vocal fold vibration stimulate the VFSCs in the MFe to accelerate production of extracellular matrices and form the layered structure is supported.
Mechanical Regulation of Human Vocal Fold Stellate Cells
TLDR
Vocal fold vibration seems to affect VF SC morphology and structure, such as cytoskeletal structure and organization, which supports the hypothesis that vocal fold vibration regulates VFSC behavior in the human MFe.
Current Understanding and Future Directions for Vocal Fold Mechanobiology.
TLDR
The purpose of this paper is to review current research on the mechanobiology of the vocal folds as it relates to growth, pathogenesis and treatment as well as to propose specific research directions that will advance understanding of this subject.
Functional Histology of the Macula Flava in the Human Vocal Fold – Part 2: Its Role in the Growth and Development of the Vocal Fold
TLDR
Human MFe including VFSCs were inferred to be involved in the metabolism of EM, essential for the viscoelasticity of the human VFM, and are considered to be an important structure in the growth and development of thehuman VFM.
Heterogeneity of Stem Cells in the Human Vocal Fold Mucosa.
  • Kiminori Sato
  • Medicine, Biology
    Advances in experimental medicine and biology
  • 2019
TLDR
The latest research shows that the cells in the human maculae flavae are involved in the metabolism of extracellular matrices that are essential for viscoelasticity in thehuman vocal fold mucosa as a vibrating tissue and are considered to be important cells inThe growth, development, and aging of the human vocal fold tissue.
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References

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TLDR
During infancy, the extracellular matrices synthesized in the maculae flavae appear in the membranous portion of the vocal fold, each at a different time, so as to initiate the 3-dimensional formation ofThe vocal fold mucosa.
Histologic Investigation of the Macula Flava of the Human Vocal Fold
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TLDR
An investigation was carried out to determine the histologic structure of the maculae flavae of human adult vocal folds, which seem to control the synthesis of fibrous components in the vocal ligament.
Histologic Investigation of the Macula Flava of the Human Newborn Vocal Fold
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TLDR
The macula flava of the newborn appears to be an important structure in the growth and development of the vocal ligament.
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TLDR
A decrease in the number and activation of fibroblasts in maculae flavae indicates decreased synthesis of fibrous components in the vocal fold mucosa, which influences the viscoelasticity and stiffness of vibrating tissue and contributes partially to aging of the voice.
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TLDR
The vocal fold stellate cells (VFSC) participate in the metabolism of the extracellular matrices essential for the viscoelastic properties of the lamina propria of the human adult vocal fold mucosa as a vibrating tissue.
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TLDR
The aim of the present study was to detect vitamin A (retinol) in the VFSC, a new category of cells in the human vocal fold that was found to differ morphologically from conventional fibroblasts.
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TLDR
The newborn VFSCs had started to synthesize extracellular matrices essential for the viscoelastic properties of the vocal fold mucosa, including collagenous fibers, reticular fibers, elastic fibers, and glycosaminoglycan.
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TLDR
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TLDR
Results of this investigation show that, when bending stiffness and variable cross section are included, the lowest normal mode frequency can more than double, depending on the strain of the ligament, suggesting that much higher phonation frequencies may be achievable than heretofore thought for a given vocal fold length.
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TLDR
The biomechanical terms of stress and strain (and stress-strain curves of human vocal folds) are related to the fibrous proteins of the vocal folds and their effect on the dynamic range of vocal pitch is presented.
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