Histopathologic features of the tumor budding in adenocarcinoma of the lung: tumor budding as an index to predict the potential aggressiveness.

@article{Yamaguchi2010HistopathologicFO,
  title={Histopathologic features of the tumor budding in adenocarcinoma of the lung: tumor budding as an index to predict the potential aggressiveness.},
  author={Yoko Yamaguchi and Genichiro Ishii and Motohiro Kojima and Kiyotaka Yoh and Hajime Otsuka and Yoichi Otaki and K. Aokage and Shingo Yanagi and Kanji Nagai and Yutaka Nishiwaki and Atsushi Ochiai},
  journal={Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer},
  year={2010},
  volume={5 9},
  pages={1361-8}
}
INTRODUCTION The term tumor budding has been applied to single cells or small clusters of up to four cells within the stromal tissue at the invasive margin of colorectal cancers. This morphologic feature is increasingly being recognized as an adverse prognostic factor. The purpose of this study was to evaluate the clinicopathologic significance of tumor budding in adenocarcinomas of the lung. METHODS We investigated the relationship between tumor budding and clinicopathologic parameters of… CONTINUE READING